Protective effects of erdosteine and vitamins C and E combination on ischemia-reperfusion-induced lung oxidative stress and plasma copper and zinc levels in a rat hind limb model.
作者： Mehmet Sırmalı , Efkan Uz , Rana Sırmalı , Aynur Kılbaş , H. Ramazan Yılmaz
DOI: 10.1007/S12011-007-0010-3
关键词:
摘要: The aim of this study was to investigate the protective effects erdosteine and vitamins C E (VCE) on lungs after performing hind limb ischemia–reperfusion (I/R) by assessing oxidative stress, plasma copper (Cu), zinc (Zn) analysis. animals were divided randomly into four groups as nine rats each follows: control, I/R, I/R plus erdosteine, VCE combination. period for 60 min performed both limbs all in with allowing 120 min reperfusion. received orally one time a day 3 days before group. In group, combination although placebo given control group animals. Lung lipid peroxidation (malondialdehyde [MDA]) level, superoxide dismutase (SOD), catalase activities increased, lung glutathione (GSH) Zn levels decreased tissue compared Serum MDA creatine kinase, lactate dehydrogenase increased control. SOD activity administration, whereas GSH increased. Cu I/R. conclusion, has an antioxidant role values rat model, it more affect than attenuating I/R-induced injury rats.
springer.com
sci-hub.se 参考文章(38)
H.W. Gordon Baker, James Brindle, D. Stewart Irvine, R. John Aitken, Protective effect of antioxidants on the impairment of sperm motility by activated polymorphonuclear leukocytes. Fertility and Sterility. ,vol. 65, pp. 411- 419 ,(1996) , 10.1016/S0015-0282(16)58109-6
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
P.D. Whanger, Selenium and the brain: a review. Nutritional Neuroscience. ,vol. 4, pp. 81- 97 ,(2001) , 10.1080/1028415X.2001.11747353
H.H. Draper, M. Hadley, MALONDIALDEHYDE DETERMINATION AS INDEX OF LIPID PEROXIDATION Methods in Enzymology. ,vol. 186, pp. 421- 431 ,(1990) , 10.1016/0076-6879(90)86135-I
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
J.A. Woolliams, G. Woolliams, P.H. Anderson, C.H. Mcmurray, Variation in the Activities of Glutathione Peroxidase and Superoxide Dismutase and in the Concentration of Copper in the Blood in Various Breed Crosses of Sheep Research in Veterinary Science. ,vol. 34, pp. 253- 256 ,(1983) , 10.1016/S0034-5288(18)32219-7
Donna L. Carden, D. Neil Granger, PATHOPHYSIOLOGY OF ISCHAEMIA-REPERFUSION INJURY The Journal of Pathology. ,vol. 190, pp. 255- 266 ,(2000) , 10.1002/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6
Ruth Simpson, Rafael Alon, Lester Kobzik, C. Robert Valeri, David Shepro, Herbert B. Hechtman, Neutrophil and Nonneutrophil-Mediated Injury in Intestinal Ischemia-Reperfusion Annals of Surgery. ,vol. 218, pp. 444- 454 ,(1993) , 10.1097/00000658-199310000-00005
Monica Dal Sasso, Maria Culici, Enrico Eugenio Guffanti, Tiziana Bianchi, Elena Fonti, Pier Carlo Braga, A combination of budesonide and the SH-metabolite I of erdosteine acts synergistically in reducing chemiluminescence during human neutrophil respiratory burst. Pharmacology. ,vol. 74, pp. 127- 134 ,(2005) , 10.1159/000084295
Mukadder Çalikoglu, Lulufer Tamer, Nehir Sucu, Banu Coskun, Bahadir Ercan, Ali Gul, Ilker Calikoglu, Arzu Kanik, The effects of caffeic acid phenethyl ester on tissue damage in lung after hindlimb ischemia-reperfusion. Pharmacological Research. ,vol. 48, pp. 397- 403 ,(2003) , 10.1016/S1043-6618(03)00156-7