Stroke Longitudinal Volumetric Measures Correlate with the Behavioral Score in Non-Human Primates.

摘要: Abstract Stroke is the second leading cause of death worldwide. Brain imaging data from experimental rodent stroke models suggest that size and location ischemic lesion relate to behavioral outcome. However, such a relationship between these two variables has not been established in Non-Human Primate (NHP) models. Thus, we aimed evaluate whether size, location, severity following controlled Middle Cerebral Artery Occlusion (MCAO) NHP model correlated neurological Forty cynomolgus macaques underwent MCAO, after four mortalities, thirty-six subjects were followed up during longitudinal study. Structural T2 scans obtained by magnetic resonance (MRI) prior to, 48 h, 30 days post-MCAO. Neurological function was assessed with Non-human Scale (NHPSS). whole volume calculated per subject. At chronic stages, remaining brain computed, affected hemisphere parceled into 50 regions interest (ROIs). Whole volumetric measures analyzed relation NHPSS score. The evaluation showed positive correlation score, whereas negatively NHPSS. Following ROI parcellation, outcome frontal, temporal, occipital, middle white matter, as well internal capsule, superior temporal gyri, caudate nucleus. These results represent an important step translational research demonstrating close similarities clinical characteristics human illustrating significant areas could targets for novel neuroprotective strategies.