Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging

摘要: Peripheral nerves from aged animals exhibit features of degeneration, including marked fiber loss, morphological irregularities in myelinated axons and notable reduction the expression myelin proteins. To investigate how protein homeostatic mechanisms change with age within peripheral nervous system, we isolated Schwann cells sciatic young old rats. The responsiveness to stress stimuli is weakened, which part may account for observed age-associated alterations glial axonal proteins vivo. Although calorie restriction known slow aging process central its influence on has not been investigated detail. determine if dietary beneficial nerve health function, studied rats four distinct ages (8, 18, 29 38 months) kept an ad libitum (AL) or a 40% restricted diet. Age-associated major widening nodes Ranvier are attenuated by intervention, paralleled maintenance differentiated cell phenotype. improvements architecture diet restriction, part, underlined sustained chaperones markers autophagy-lysosomal pathway. Together, vitro vivo results suggest that there might be age-limit intervention needs initiated elicit response health.