Determination of the α,β-adrenoceptor blocker YM-09538 in plasma by high-performance liquid chromatography with fluorescence detection
作者： Hidetaka Kamimura , Hirokazu Sasaki , Shigeo Kawamura
DOI: 10.1016/S0378-4347(00)80250-9
关键词:
摘要: A high-performance liquid chromatographic method for the determination of α,β-adrenoceptor blocker 5-{1-hydroxy-2-[2-(o-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulphonamide hydrochloride (YM-09538) in plasma, using 5-di-n-butylaminonaphthalene-1-sulphonyl chloride as a reagent fluorescence labelling, is described. The detection limit 20 ng/ml, which sensitive enough to determine YM-09538 plasma levels after oral administration effective doses dogs and humans.
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