Molecular Profiles for Lung Cancer Pathogenesis and Detection in U.S. Veterans

摘要: Abstract : During our first year of research, we demonstrated a localized field cancerization phenomenon on gene expression in the airway patients with lung cancer, and identified several pathways preferentially activated adjacent to tumors. In addition, have markers stem cells that may represent tumor-initiating are evaluating profiles these cells. We Snail as novel marker promote epithelial-mesenchymal transition. made major technical advance developing methods required use low quality quantity laser capture microdissected material sequence transcriptome. This allows us examine premalignant lesions compare it histologically normal epithelium tumor. validated this approach data will allow identify for carcinogenesis. All studies identifying biomarkers could be used early cancer detection involved cancerization. Understanding development is likely shed light carcinogenesis lead diagnostic tests, therapies chemoprevention strategies cancer.