Direct determination of hydrazine, methylhydrazine, and 1,1-dimethylhydrazine by zwitterionic hydrophilic interaction liquid chromatography with amperometric detection

摘要: ABSTRACTA promising alternative to ion-chromatographic methods currently used for the direct determination of hydrazines is provided by hydrophilic interaction liquid chromatography (HILIC). In this work, we propose a method simultaneous hydrazine, methylhydrazine and 1,1-dimethylhydrazine in natural waters soils based on combination chromatographic separation zwitterionic sulfobetaine stationary phase (Nucleodur HILIC) HILIC mode with amperometric detection.Effects different factors retention analytes were studied optimum conditions analysis found. We recommend mixture acetonitrile an aqueous phosphate buffer solution pH 2.5 (78:22 v/v) ionic strength 20 mM as mobile phase. Detection current was performed at working electrode potential 1.1 V.The advantages are high efficiency separation, rapidity, sensitivity wide dynamic range analyte concentrati...