Cyclic nucleotide signalling in malaria parasites.

摘要: The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and guanosine (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a change function through activation of their respective nucleotide-dependent protein kinases, PKA PKG. enzymatic components the malaria parasite nucleotide signalling pathways have been identified, genetic biochemical studies these enzymes carried out date reviewed herein. What has become very clear is that play vital roles controlling every stage complex life cycle. Our understanding involvement orchestrating biology parasites still its infancy, but recent advances our tools increasing interest will deliver more rapid progress coming years.