Factor XI in haemostasis and thrombosis: Past, present and future

摘要: Thromb Haemost 2007; 98: 84–89 The discipline of haemostasis and thrombosis has set an example, perhaps more than other disciplines Medicine, in discoveries based on observations the so called “experiments nature”. During a relatively short time 13 years (1947 – 1960), most coagulation factors were identified patients who presented with bleeding tendency worked up by rather simple laboratory assays.This era was followed characterization biochemical reactions involved blood coagulation, delineation sequence pathways recently unraveling molecular genetic aspects various components. objective this review is to describe some major developments understanding role factor (F)XI that have occurred over 50 research, highlight recent evidence which suggests FXI deficiency can antithrombotic effect.