Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum.

摘要: Jaw1 is a novel lymphoid-restricted gene that expressed in developmentally regulated fashion both the B and T cell lineages. mRNA abundantly pre-B lines with minimal or undetectable expression plasma lines. Pre-T normal mouse thymocytes express high levels of mRNA, whereas most mature low levels. Comparison human genes reveals encodes 539 amino acid protein highly conserved coiled-coil domain middle third COOH-terminal transmembrane domain. was localized to endoplasmic reticulum (ER) lymphocytes by indirect immunofluorescence confocal microscopy. When overexpressed HeLa cells, targeted ER. In vitro translation presence canine microsomes demonstrated an integral membrane ER oriented on facing cytosol. member class proteins hydrophobic anchors structurally similar involved vesicle targeting fusion. These findings suggest function and/or structure may be modified resident proteins.