Hepatitis C, iron status, and disease severity: Relationship with HFE mutations☆

摘要: Background & Aims: Mild to moderate hepatic iron loading is common in patients with chronic hepatitis C. We sought determine whether mutations the hemochromatosis gene, HFE, are associated overload and acceleration of disease progression C patients. Methods: A total 316 were studied: 198 consecutive undergoing liver biopsy for compensated 118 who underwent transplantation end-stage disease. Serum studies, quantitative concentration, histologic activity index, HFE genotype determined. Results: Among disease, presence was independently elevations serum level, transferrin-iron saturation, ferritin index (P < 0.05). After adjustment duration infection virus, also bridging fibrosis or cirrhosis (odds ratio, 18; 95% confidence interval, 1.7–193). not There no significant difference prevalence between (42% vs. 33%, respectively; P = 0.67). Conclusions: The advanced from C, especially after controlling These results suggest that accelerate but may be responsible