Overexpression of Constitutively Active PKG‐I Protects Female, But Not Male Mice From Diet‐Induced Obesity

摘要: Cyclic guanosine monophosphate (cGMP)–dependent protein kinase I (PKG-I) is a multifunctional protein. The direct effects of PKG-I activation on energy homeostasis and obesity development are not well understood. Herein, we generated transgenic mice with expression the constitutively active in adipose tissue as other tissues. Male female overexpressing were fed low-fat (LF) or high-fat (HF) diet for 16 weeks. HF-fed had decreased body weight gain, lower percentage fat, improved glucose tolerance compared to wild-type (WT) controls. In contrast, male resistant HF-diet-induced obesity, exhibited similar levels adiposity intolerance WT Furthermore, found that increased expenditure cold-induced adaptive thermogenesis controls, which was associated uncoupling protein-1 (UCP1) brown (BAT). addition, rates lipolysis white (WAT) also controls due phosphorylation hormone-sensitive lipase (HSL). However, mice, WAT between Together, these data demonstrate sex differences regulation function its contribution induced obesity.