Prevalence of and factors associated with obstructive sleep apnea in a cohort of adults with long duration type 1 diabetes mellitus

摘要: Chronic health conditions like diabetes and sleep disorders have been increasing. Previous research showed that are interrelated. The majority of studies examining this relationship focused on type 2 diabetes. Although a between 1 (T1D) has studied, investigations limited to youth small samples. We, therefore, aimed assess the prevalence, overall gender-specific, correlates, obstructive apnea (OSA) risk in an adult cohort with long-standing T1D. A total 170 individuals T1D attending 25-year follow-up Pittsburgh Epidemiology Diabetes Complications study who completed OSA screening tool, Berlin Questionnaire (BQ), were included cross-sectional analysis. Those scoring positively BQ and/or reported previous diagnosis classified as being at high risk. The prevalence was 25.9% (25.0% among men, 26.6% women). High versus low-OSA-risk differed univariately respect markers obesity, systolic blood pressure, estimated glucose disposal rate, lipid profile, smoking history, although no differences observed hemoglobin A1c. In final multivariable model, adjusting for sex duration, body mass index (BMI) (directly, p=0.01), high-density lipoprotein (HDL) (inversely, p=0.03), history p=0.04) correlated gender-specific analyses, BMI p=0.007) HDL p=0.03) also associated women, while diastolic pressure (p=0.01) (p=0.04) positive correlates men. Our findings suggest adults is comparable general population. Given both tools treatment widely available, identifying already burdened serious chronic disease public importance. Indeed, modifiable factors independently study, suggesting adoption healthier lifestyle may reduce T1D, improving wellbeing reducing subsequent further complication development. Future prospective cohorts should be conducted explore hypothesis.