Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients.
作者： Pengfeng Zhu , Qingqing Tan , Wen Jiang , Yangjun Ou , Peizhen Xu
DOI: 10.3233/CBM-182114
关键词:
摘要: OBJECTIVE This study aimed to detect the expression of eukaryotic translation initiation factor 3B (EIF3B) and investigate its correlation with tumor features survival in cervical cancer patients. METHODS retrospectively reviewed 187 (squamous cell carcinoma) patients underwent resection. Immunohistochemistry was performed determine EIF3B tissue samples. Besides, disease free (DFS) overall (OS) were calculated. The median follow-up duration 69 months, last date 2017/12/31. RESULTS higher compared paired adjacent (45.5% vs. 32.1%, P= 0.015). high associated Federation Gynecology Obstetrics (FIGO) Stage (P= 0.001) presence lymph node metastasis 0.002). As profiles, Kaplan-Meier curves disclosed that DFS (P< OS both shorter group low group. Multivariate Cox's regression analysis expression, pathological grade III (vs I/II) FIGO III/IV independent predictive factors for unfavorable as well (all P value < 0.05). CONCLUSION is overexpressed, correlates Stage, profiles
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