Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe.
作者： Dmitriy Berillo , Bo Mattiasson , Igor Yu. Galaev , Harald Kirsebom
DOI: 10.1016/J.JCIS.2011.11.006
关键词:
摘要: Abstract In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)–diphenylalanine (Phe–Phe) peptides induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls densely packed fibres assembled dipeptides and pores the range 10–100 μm. Hydrogels from same composition above freezing point homogenous without any apparent porosity. The gels characterised microscopy techniques, CD-spectroscopy stress sweeps. less mechanical strength than might be due to former. It appeared self-assembled peptide both cryo- hydrogel maintained β-sheet commonly attributed these.
harvard.edu
nu.edu.kz
elsevier.com参考文章(23)
Richard G. Weiss, Pierre Terech, Molecular Gels: Materials with Self-Assembled Fibrillar Networks mgms. ,(2005)
D L Williams-Smith, R C Bray, M J Barber, A D Tsopanakis, S P Vincent, Changes in apparent pH on freezing aqueous buffer solutions and their relevance to biochemical electron-paramagnetic-resonance spectroscopy. Biochemical Journal. ,vol. 167, pp. 593- 600 ,(1977) , 10.1042/BJ1670593
David K. Smith, Building bridges Nature Chemistry. ,vol. 2, pp. 162- 163 ,(2010) , 10.1038/NCHEM.566
Y. Pocker, Edmond. Green, Hydrolysis of D-glucono-.delta.-lactone. I. General acid-base catalysis, solvent deuterium isotope effects, and transition state characterization Journal of the American Chemical Society. ,vol. 95, pp. 113- 119 ,(1973) , 10.1021/JA00782A019
Harald Kirsebom, Gabriel Rata, Daniel Topgaard, Bo Mattiasson, Igor Yu. Galaev, Mechanism of Cryopolymerization: Diffusion-Controlled Polymerization in a Nonfrozen Microphase. An NMR Study Macromolecules. ,vol. 42, pp. 5208- 5214 ,(2009) , 10.1021/MA900566D
Xiao-Li Sun, Wei-Dong He, Jian Li, Li-Ying Li, Bo-Yu Zhang, Ting-Ting Pan, RAFT cryopolymerizations of N,N‐dimethylacrylamide and N‐isopropylacrylamide in moderately frozen aqueous solution Journal of Polymer Science Part A. ,vol. 47, pp. 6863- 6872 ,(2009) , 10.1002/POLA.23725
Yan Zhang, Hongwei Gu, Zhimou Yang, Bing Xu, Supramolecular Hydrogels Respond to Ligand−Receptor Interaction Journal of the American Chemical Society. ,vol. 125, pp. 13680- 13681 ,(2003) , 10.1021/JA036817K
Vladimir I. Lozinsky, Lilija G. Damshkaln, Konstantin O. Bloch, Pnina Vardi, Natalia V. Grinberg, Tatiana V. Burova, Valerij Y. Grinberg, Cryostructuring of polymer systems. XXIX. Preparation and characterization of supermacroporous (spongy) agarose‐based cryogels used as three‐dimensional scaffolds for culturing insulin‐producing cell aggregates Journal of Applied Polymer Science. ,vol. 108, pp. 3046- 3062 ,(2008) , 10.1002/APP.27908
Sophie Toledano, Richard J. Williams, Vineetha Jayawarna, Rein V. Ulijn, Enzyme-Triggered Self-Assembly of Peptide Hydrogels via Reversed Hydrolysis Journal of the American Chemical Society. ,vol. 128, pp. 1070- 1071 ,(2006) , 10.1021/JA056549L
S. Scanlon, A. Aggeli, N. Boden, R.J. Koopmans, R. Brydson, C.M. Rayner, Peptide aerogels comprising self-assembling nanofibrils Micro & Nano Letters. ,vol. 2, pp. 24- 29 ,(2007) , 10.1049/MNL:20070006