Infection of a cell line of mouse L fibroblasts with scrapie agent.

摘要: THE infection of cell cultures with the causative agents subacute spongiform encephalopathies — scrapie, kuru, Creutzfeldt–Jakob disease and transmissible mink encepha-lopathy—has not yet been reported. The development a line (SMB), from brain mouse affected in which agent multiplies has shown that replication vitro is possible1. Studies this have, however, limited because no control culture was available for comparative studies. This limitation now, part, overcome by successful L cells scrapie agent, as described here.