Defining high HIV incidence subgroups of Australian homosexual men: implications for conducting HIV prevention trials in low HIV prevalence settings.

摘要: Objectives The aim of the study was to assess whether subpopulations with sufficiently high HIV incidences for prevention trials can be identified in low incidence settings such as Australia. Methods In a community-based cohort HIV-negative homosexually active men Sydney, Australia, potential risk factors associated an annual ≥2 per 100 person-years (PY) were identified. A stepwise procedure ranked these according incidence, create ‘high-incidence’ subgroup participants. Willingness participate assessed. Results Although overall only 0.78 PY, nine variables 2 PY or greater. Stepwise inclusion revealed representing 24% total follow-up time combined 2.71 who reported at least one three past 6 months. These more willing than others vaccine and antiretroviral therapy trials. Conclusions These findings demonstrate that it is possible identify low-incidence are above average willingness trials.