Secondary Deuterium Kinetic Isotope Effects and Transition State Structure

作者: Olle Matsson , Kenneth C. Westaway

DOI: 10.1016/S0065-3160(08)60194-X

关键词:

摘要: Publisher Summary This chapter is concerned with secondary deuterium kinetic isotope effects. The illustrates some of the important recent advances in interpretation and uses these effects to elucidate reaction mechanisms. Other excellent reviews (KIEs) have also been discussed chapter. demonstrates ways which tritium KIEs can be used mechanisms reactions determine structure their transition states. Secondary a-deuterium widely mechanism S N Some significant studies illustrating principles are presented this In particular, advantages using both theoretical calculations experimental data solve problems emphasized

参考文章(177)
Ian H. Williams, Theoretical modeling of compression effects in enzymic methyl transfer Journal of the American Chemical Society. ,vol. 106, pp. 7206- 7212 ,(1984) , 10.1021/JA00335A058
L.S. Bartell, Secondary isotope effects and mass-sensitive amplitudes of vibration Tetrahedron Letters. ,vol. 1, pp. 13- 16 ,(1960) , 10.1016/S0040-4039(01)99285-8
Takashi Ando, Hiroshi Tanabe, Hiroshi Yamataka, Kinetic isotope effects in the Menshutkin-type reaction of benzyl benzenesulfonates with N,N-dimethylanilines. Variation in the transition-state structure Journal of the American Chemical Society. ,vol. 106, pp. 2084- 2088 ,(1984) , 10.1021/JA00319A030
Alf Thibblin, Per Ahlberg, Reaction branching and extreme kinetic isotope effects in the study of reaction mechanisms Chemical Society Reviews. ,vol. 18, pp. 209- 224 ,(1989) , 10.1039/CS9891800209
L. S. Bartell, The Role of Non-bonded Repulsions in Secondary Isotope Effects. I. Alpha and Beta Substitution Effects.1 Journal of the American Chemical Society. ,vol. 83, pp. 3567- 3571 ,(1961) , 10.1021/JA01478A006
John W. Hill, Arthur. Fry, Chlorine Isotope Effects in the Reactions of Benzyl and Substituted Benzyl Chlorides with Various Nucleophiles Journal of the American Chemical Society. ,vol. 84, pp. 2763- 2769 ,(1962) , 10.1021/JA00873A025
Russell J. Boyd, Chan Kyung Kim, Zheng Shi, Noham Weinberg, Saul Wolfe, Secondary H/D isotope effects and transition state looseness in nonidentity methyl transfer reactions. Implications for the concept of enzymic catalysis via transition state compression. Journal of the American Chemical Society. ,vol. 115, pp. 10147- 10152 ,(1993) , 10.1021/JA00075A033
Daisy Zhang, Gerhard L. Closs, Dutch D. Chung, James R. Norris, Free energy and entropy changes in vertical and nonvertical triplet energy transfer processes between rigid and nonrigid molecules. A laser photolysis study Journal of the American Chemical Society. ,vol. 115, pp. 3670- 3673 ,(1993) , 10.1021/JA00062A036
Jonas Persson, Svante Axelsson, Olle Matsson, Solvent Dependent Leaving Group Fluorine Kinetic Isotope Effect in a Nucleophilic Aromatic Substitution Reaction Journal of the American Chemical Society. ,vol. 118, pp. 20- 23 ,(1996) , 10.1021/JA952003V