The Therapeutic Potential of Quercetin in Parkinson's Disease: Insights into its Molecular and Cellular Regulation.

摘要: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in substantia nigra pars compacta (SNc). PD multifactorial disorder, with several different factors being suggested to play synergistic pathophysiological role, including oxidative stress, autophagy, underlying pro-inflammatory events neurotransmitters abnormalities. Overall, can be viewed as product complex interaction environmental acting on given genetic background. The importance this subject has gained more attention discover novel therapies prevent well treat PD. According previous research, drugs used have indicated significant limitations. Therefore, role flavonoids been extensively studied treatment. Quercetin, plant flavonol from flavonoid group, considered supplemental therapy for Quercetin pharmacological functions controlling molecular pathways. Although few studies intended evaluate basis use quercetin context conducted so far, at present, there very little evidence available addressing mechanisms action. Various principal aspects these treatment procedures remain unknown. Here, currently existing knowledge supporting clinical management reviewed.