Phase II study of oral vitamin B12 supplementation as an alternative to intramuscular injection for patients with non-small cell lung cancer undergoing pemetrexed therapy

作者: Yusuke Takagi , Yukio Hosomi , Makoto Nagamata , Kageaki Watanabe , Satoshi Takahashi

DOI: 10.1007/S00280-015-2954-X

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摘要: Purpose A vitamin B12 supplement is required in pemetrexed single agent therapy. Intramuscular administration the method of choice; however, oral simpler and easier may be sufficiently effective. We conducted a Phase II study to evaluate safety patients with advanced non-small cell lung cancer who received

参考文章(13)
Yusuke Takagi, Yukio Hosomi, Kuniko Sunami, Yoshiro Nakahara, Yusuke Okuma, Makiko Yomota, Tsuneo Shimokawa, Makoto Nagamata, Mari Iguchi, Hiroaki Okamoto, Tatsuru Okamura, Masahiko Shibuya, A Prospective Study of Shortened Vitamin Supplementation Prior to Cisplatin–Pemetrexed Therapy for Non-Small Cell Lung Cancer Oncologist. ,vol. 19, pp. 1194- 1199 ,(2014) , 10.1634/THEONCOLOGIST.2014-0221
Bernard Favrat, Paul Vaucher, Lilli Herzig, Bernard Burnand, Giuseppa Ali, Olivier Boulat, Thomas Bischoff, François Verdon, Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic randomised controlled trial. BMC Family Practice. ,vol. 12, pp. 2- 2 ,(2011) , 10.1186/1471-2296-12-2
David A. Rinaldi, John G. Kuhn, Howard A. Burris, F. Andrew Dorr, Gladys Rodriguez, S. Gail Eckhardt, Suzanne Jones, James R. Woodworth, Sharyn Baker, Connie Langley, David Mascorro, Trent Abrahams, Daniel D. Von Hoff, A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. Cancer Chemotherapy and Pharmacology. ,vol. 44, pp. 372- 380 ,(1999) , 10.1007/S002800050992
Yuichiro Ohe, Yukito Ichinose, Kazuhiko Nakagawa, Tomohide Tamura, Kaoru Kubota, Nobuyuki Yamamoto, Susumu Adachi, Yoshihiro Nambu, Toshio Fujimoto, Yutaka Nishiwaki, Nagahiro Saijo, Masahiro Fukuoka, Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer. Clinical Cancer Research. ,vol. 14, pp. 4206- 4212 ,(2008) , 10.1158/1078-0432.CCR-07-5143
Yusuke Takagi, Akira Toriihara, Yoshiro Nakahara, Makiko Yomota, Yusuke Okuma, Yukio Hosomi, Masahiko Shibuya, Tatsuru Okamura, Eligibility for Bevacizumab as an Independent Prognostic Factor for Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Cohort Study PLoS ONE. ,vol. 8, pp. e59700- ,(2013) , 10.1371/JOURNAL.PONE.0059700
Nicholas J. Vogelzang, James J. Rusthoven, James Symanowski, Claude Denham, E. Kaukel, Pierre Ruffie, Ulrich Gatzemeier, Michael Boyer, Salih Emri, Christian Manegold, Clet Niyikiza, Paolo Paoletti, Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma Journal of Clinical Oncology. ,vol. 21, pp. 2636- 2644 ,(2003) , 10.1200/JCO.2003.11.136
Shrikanta Chattopadhyay, Richard G. Moran, I. David Goldman, Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications Molecular Cancer Therapeutics. ,vol. 6, pp. 404- 417 ,(2007) , 10.1158/1535-7163.MCT-06-0343
Simone J. P. M. Eussen, Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency Archives of Internal Medicine. ,vol. 165, pp. 1167- 1172 ,(2005) , 10.1001/ARCHINTE.165.10.1167
Martin H. Cohen, John R. Johnson, Yong‐Cheng Wang, Rajeshwari Sridhara, Richard Pazdur, FDA Drug Approval Summary: Pemetrexed for Injection (Alimta®) for the Treatment of Non-Small Cell Lung Cancer Oncologist. ,vol. 10, pp. 363- 368 ,(2005) , 10.1634/THEONCOLOGIST.10-6-363
Axel‐R. Hanauske, Victor Chen, Paolo Paoletti, Clet Niyikiza, Pemetrexed Disodium: A Novel Antifolate Clinically Active Against Multiple Solid Tumors Oncologist. ,vol. 6, pp. 363- 373 ,(2001) , 10.1634/THEONCOLOGIST.6-4-363