Evidence for Two Bladder Cancer Suppressor Loci on Human Chromosome 9

摘要: Most carcinomas of the bladder show loss heterozygosity for markers on human chromosome 9, which suggests that one or more tumor suppressor genes are located this chromosome. Several observations suggest such alterations an important early step in tumorigenesis. We analyzed pattern allelic 46 primary using 19 polymorphic from 9. While most tumors with showed all informative were tested, six demonstrated only partial Two contained deletions predominantly involved q arm, as shown by previous studies. The other four exclusively p a common region between D9S161 (9p21) and telomere. results there is no single 9 identify two distinct regions may contain loci.