DNA damage signalling in eukaryotes: learning from budding yeast
作者： Mauricio Menacho Márquez , José Ramón Murguía Ibáñez
DOI: 10.1007/BF02712848
关键词:
摘要: Cell cycle checkpoints ensure the order of cell events to preserve genome integrity. Among those, DNA damage prevent chromosome segregation when is damaged. Defects in signalling impair ability repair lesions leading cancer predisposition humans. Advances budding yeast have underlined regulatory networks for these pathways, which are conserved throughout evolution, allowing a better understanding how controls sense and transduce signal. However, molecular basis recognition coordinated regulation by checkpoint still remain unclear.
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