Multidisciplinary Clinic Dedicated to Treating Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome: Presenting Characteristics of the First 47 Consecutive Patients
作者： Jennifer Frankovich , Margo Thienemann , Jennifer Pearlstein , Amber Crable , Kayla Brown
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摘要: Abstract Background: Abrupt, dramatic onset obsessive-compulsive disorder (OCD) and/or eating restriction with at least two coinciding symptoms (anxiety, mood dysregulation, irritability/aggression/oppositionality, behavioral regression, cognitive deterioration, sensory or motor abnormalities, somatic symptoms) defines pediatric acute-onset neuropsychiatric syndrome (PANS). Descriptions of clinical data in such youth are limited. Methods: We reviewed charts 53 consecutive patients evaluated our PANS Clinic; 47 met symptom criteria but not all the requirement for “acute onset.” Patients meeting full were compared who had a subacute/insidious symptoms. Results: Nineteen (40%) study acute In these patients, autoimmune/inflammatory diseases and psychiatric disorders common first-degree family members (71% 78%, respectively). Most relapsing/remitting course (84%), promi...
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