Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects.

摘要: Purpose To assess whether baseline retinal nerve fiber layer (RNFL) measurements obtained with optical coherence tomography (OCT2; Carl Zeiss Meditec, Dublin, California, USA) are predictive of the development glaucomatous change. Design Cohort study. Methods Participants were recruited from University San Diego (UCSD) longitudinal Diagnostic Innovations in Glaucoma Study (DIGS). One eye was studied each 114 glaucoma suspects normal standard automated perimetry (SAP) and OCT RNFL imaging at baseline. The cohort divided into two groups based on change (repeatable abnormal visual fields and/or a stereophotographic appearance optic disk). Cox proportional hazards models used to determine ability thickness measurements. Results Over 4.2-year average follow-up period, 23 eyes (20%) developed changes 91 (80%) did not. At baseline, thinner measurements, higher SAP pattern deviation (PSD), “glaucoma” stereophotograph assessment, central corneal (CCT) associated study endpoints univariate analysis. After adjusting for age, intraocular pressure (IOP), CCT, PSD multivariate models, 10 μm average, superior inferior [hazard ratio (95% CI); 1.51 (1.11 2.12), 1.57 (1.17 2.18), 1.49, (1.19 1.91), respectively]. consistent when assessment included Conclusions Thinner suspect eyes. thinning an independent predictor change, even IOP, PSD.