Bioactive Metabolites Produced by Pseudonocardia endophytica VUK-10 from Mangrove Sediments: Isolation, Chemical Structure Determination and Bioactivity.

摘要: Chemical investigation of the actinobacterial isolate Pseudonocardia endophytica VUK-10 has led to segregation two known bioactive compounds, namely 4-(2-acetamidoethyl) phenyl acetate and 4-((1, 4-dioxooctahydropyrrolo [1, 2-a] pyrazin-3-yl) methyl) acetate. The strain was isolated from a sediment sample Nizampatnam mangrove ecosystem, south coastal Andhra Pradesh, India. chemical structure active compounds established on basis spectroscopic analysis, including (1)H NMR (13)C spectroscopies, FTIR, EIMS. antimicrobial cytotoxic activities produced by were tested against opportunistic pathogenic bacteria fungi MDA-MB-231, OAW, HeLa, MCF-7 cell lines. exhibited gram-positive gram-negative also showed potent activity This is first example for this class origin.