Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial

摘要: Major surgery induces a long fasting time and provokes an inflammatory response which increases the risk of infections. Nutrition given before during can avoid has been shown to increase arginine/asymmetric dimetlhylarginine ratio, marker nitric oxide availability, in cardiac tissue increased concentrations branched chain amino acids blood plasma. However, effect this new nutritional strategy on organ is unknown. Therefore, we studied nutrition myocardial response. In trial, 32 patients were randomised between enteral, parenteral, no supplementation (control) from 2 days before, during, up after coronary artery bypass grafting. Both solutions included proteins or acids, glucose, vitamins, minerals. Myocardial atrial was sampled revascularization analysed immunohistochemically, subdivided into cardiomyocytic, fatty, fibrotic areas. Inflammatory cells, especially leukocytes, present all study groups. No significant differences found control conclusion, neither stimulates nor diminishes undergoing The trial registered Netherlands Trial Register (NTR): NTR2183.