4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

作者: Adrienne H Long , Waleed M Haso , Jack F Shern , Kelsey M Wanhainen , Meera Murgai

DOI: 10.1038/NM.3838

关键词:

摘要: … Exhausted T cells have low proliferative and cytokine producing capacities, have high rates of apoptosis and express high levels of inhibitory receptors such as PD-1, TIM-3 and LAG-3 (…

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