Effects of Blood Glucose Rate of Changes on Perceived Mood and Cognitive Symptoms in Insulin-Treated Type 2 Diabetes

摘要: Studies indicate that diabetes affects mood, cognitive function, and motor performance (1–5). As dysfunction depressive mood symptoms have been reported with hyperglycemia (5–7), we hypothesized the impact of insulin on blood glucose parameters would affect symptoms. Consistent our past post hoc findings (7), specifically rapid pre- to postmeal rate change (BGRATE) correlates negative but not energy or positive mood. We report results correlation analyses BGRATE from a pilot investigation designed evaluate whether improvements in glycemic control seen basal plus prandial analog regimens compared patients type 2 (8–10) lead measurable differences. A single-center, open-label, crossover, randomized, controlled clinical trial enrolled 60 adults diabetes, A1C 7–10%, prestudy use metformin (with without oral antihyperglycemic medications once daily insulin). Pregnant breast-feeding women previous diagnosis depression treated centrally acting (e.g., antidepressants anxiolytics) were excluded. Patients randomly assigned treatment Humalog Mix 75/25 (insulin lispro mixture [75% protamine suspension/25% …