作者: Pier Paolo Di Fiore , Simona Polo , Kay Hofmann
DOI: 10.1038/NRM1124
关键词:
摘要: Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins partners contain distinct ubiquitin-binding domains. We also put forward speculative models regulation versus polyubiquitylation.