When ubiquitin meets ubiquitin receptors: a signalling connection

作者: Pier Paolo Di Fiore , Simona Polo , Kay Hofmann

DOI: 10.1038/NRM1124

关键词:

摘要: Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins partners contain distinct ubiquitin-binding domains. We also put forward speculative models regulation versus polyubiquitylation.

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