Flexible $3\times3$ Mueller Matrix Endoscope Prototype for Cancer Detection

摘要: In this paper, we research and design a flexible head-modulated polarization endoscope system prototype for early cancer detection in vivo. The new idea of our is the implementation distal tip structure, that is, has integrated state generator (PSG) analyzer (PSA), illumination fiber, image capture device. A closed-loop motion control was adopted to accurately rotate linear polarizers PSG PSA. high-definition transfer used polarized images. By design, $3\times 3$ Mueller matrix could be calculated through such an head. Furthermore, measurement process would not influenced by disturbance induced pathway light transmission. calibration carried out on PSA keep high degree accuracy repeatability described rotation-based polarization, results showed its effectiveness. Finally, head measure nude mice skin with subcutaneous implantation HeLa cells corresponding decomposition transformation parameters extracted proposed device can clearly stably distinguish cancerous normal tissues. prove potential application detection.