Chapter 12 Renal Disease in Cryoglobulinemic Vasculitis
作者： Frank Bridoux , Christophe Sirac , Arnaud Jaccard , Ramzi Abou Ayache , Jean Michel Goujon
DOI: 10.1016/S1571-5078(07)07012-2
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摘要: Publisher Summary This chapter discusses the renal disease in cryoglobulinemic vasculitis. Cryoglobulins are immunoglobulins (Ig) that precipitate as serum is cooled below body temperature and dissolve after rewarming at 37oC. They classified into three types, on basis of their Ig composition: Type-I cryoglobulins entirely made up a monoclonal Ig. cryoglobulinemia usually observed context lymphoplasmacytic proliferation, mainly Waldenstrom's macroglobulinaemia, chronic lymphocytic leukemia, or multiple myeloma. Type II (or mixed) composed two distinct components: (usually IgMk, less frequently IgG) displays specific antibody activity against polyclonal component cryoglobulin. III one several classes various pathologic conditions with immune complex formation, including infectious diseases, autoimmune disorders, malignancies, even apparently healthy individuals.
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