Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats.

摘要: Abstract Ethnopharmacological relevance Terminalia catappa L. (Combretaceae), known as “amendoeira da praia” in Brazil, has been recognized a medicinal plant folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate preventive healing effects infusion leaves T. (ILTC) against gastric lesions caused by ischemia reperfusion (I/R) injury characterize its mechanism action mucosa rats. Materials methods Different doses (30, 100, 300 mg/kg) ILTC were orally administered acute subacute treatments I/R-induced lesion After treatment, stomach rats was collected measure area, redox parameters malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) myeloperoxidase activity (MPO), interleukin 1β (IL-1β) tumor necrosis factor α (TNF-α). activities matrix metalloproteinases 2 9 (MMPs 9) assessed zymography method clarify mechanisms acceleration promoted ILTC. Results Pretreatment with (100 mg/kg) effective preventing aggravation model reducing MPO 38% relative control group, despite lack clarity this at macroscopical level area (p  Conclusion Three days could accelerate process By decreasing levels, enabled MMP-2, which led tissue recovery mucosa.