BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

作者: H. Huang , T.-J. Song , X. Li , L. Hu , Q. He

DOI: 10.1073/PNAS.0906266106

关键词:

摘要: … in the BMP/MAPK signaling pathway) with RNAi had little … /Smad signaling pathway has a dominant role in adipocyte … target gene of the BMP signaling pathway. Expression of LOX is …

参考文章(35)
Arnold I. Caplan, The Mesengenic Process Clinics in Plastic Surgery. ,vol. 21, pp. 429- 435 ,(1994) , 10.1016/S0094-1298(20)31020-8
MARION AHRENS, THOMAS ANKENBAUER, DIETMAR SCHRÖDER, ANGELA HOLLNAGEL, HUBERT MAYER, GERHARD GROSS, Expression of Human Bone Morphogenetic Proteins-2 or -4 in Murine Mesenchymal Progenitor C3H10T½ Cells Induces Differentiation into Distinct Mesenchymal Cell Lineages DNA and Cell Biology. ,vol. 12, pp. 871- 880 ,(1993) , 10.1089/DNA.1993.12.871
P Franzén, K Miyazono, P ten Dijke, H Yamashita, C H Heldin, Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 269, pp. 20172- 20178 ,(1994) , 10.1016/S0021-9258(17)32142-7
Nicole I zur Nieden, Grazyna Kempka, Derrick E Rancourt, Hans-Jürgen Ahr, Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. BMC Developmental Biology. ,vol. 5, pp. 1- 15 ,(2005) , 10.1186/1471-213X-5-1
P.R. Shepherd, L Gnudi, E Tozzo, H Yang, F Leach, B.B. Kahn, Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. Journal of Biological Chemistry. ,vol. 268, pp. 22243- 22246 ,(1993) , 10.1016/S0021-9258(18)41516-5
SIMON.C. BUTTERWITH, RONALD.S. WILKIE, MICHAEL CLINTON, Treatment of pluripotential C3H 10T1/2 fibroblasts with bone morphogenetic protein-4 induces adipocyte commitment Biochemical Society Transactions. ,vol. 24, ,(1996) , 10.1042/BST024163S
Carl-Henrik Heldin, Kohei Miyazono, Peter ten Dijke, TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature. ,vol. 390, pp. 465- 471 ,(1997) , 10.1038/37284
Shirley M. Taylor, Peter A. Jones, Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell. ,vol. 17, pp. 771- 779 ,(1979) , 10.1016/0092-8674(79)90317-9
George K. Chan, Dengshun Miao, Ron Deckelbaum, Isabel Bolivar, Andrew Karaplis, David Goltzman, Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology. ,vol. 144, pp. 5511- 5520 ,(2003) , 10.1210/EN.2003-0273
E. A. Wang, D. I. Israel, S. Kelly, D. P. Luxenberg, Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells Growth Factors Journal. ,vol. 9, pp. 57- 71 ,(1993) , 10.3109/08977199308991582