A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer

摘要: Phase contrast x-ray imaging (PCXI) is a promising modality, capable of sensitively differentiating soft tissue structures at high spatial resolution. However, sensitivity often comes the cost long exposure time or multiple exposures per image, limiting speed and possibly increasing radiation dose. Here, we demonstrate PCXI method that uses single short to capture sample phase information, permitting movies live animal imaging. The illuminates checkerboard grid produce fine grid-like intensity reference pattern detector, then spatially maps sample-induced distortions this recover differential images sample. use an improvement on our previous absorption work in two ways. There minimal loss flux, faster imaging, and, very produced for homogenous We describe how permits retrieval five from exposure; gradient horizontal vertical directions, projected depth edge-enhanced type scattering image. Finally, reconstruction technique can achieve subpixel distortion study behavior regard analysis technique, Talbot distance, time.