Predictive role of single nucleotide polymorphism (rs11614913) in the development of breast cancer in Pakistani population.
作者： Mushtaq Ahmad , Aftab Ali Shah
关键词:
摘要: Aim: miRNAs play an important role in breast cancer (BC). Variations influence their maturation, expression and consequently regulation of target genes. Materials & methods: In this study, single nucleotide polymorphism rs11614913 was genotyped BC patients (n = 300) 230 controls by employing tetra primer amplification refractory mutation system PCR Sanger sequencing (Macrogen Korea). Results: A significant difference observed the genotypes through co-dominant (χ2.#x00A0;= 42.03; p < 0.0001), additive (odds ratio [OR] 0.6441 [0.4887-0.8490, 95% confidence interval]; 0.0019), dominant (OR 0.3996 [0.2809-0.5686], 0.0001) recessive 0.2993 [0.1220-0.7347], 0.009) statistical models showed decreased risk association C allele with BC. Conclusion: Females having CT genotype are at higher as compared those CC genotype.
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