Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology.

摘要: AbstractFormed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated less explored. A common morphology supramolecular is nanofibrils, which coincidentally resembles nanofibrils formed proteins such as prions. So these termed prion-like (PriSM). Emerging evidence from several unrelated fields over past decade implies significance PriSM medicine. This perspective aims to highlight some recent advances research on PriSM. paper starts with description intriguing similarities between prions, discusses paradoxical features PriSM, introduces methods for elucidating biological functions illustrates examples beneficial aspects finishes promises current challenges We anticipate that researc...