Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat.

摘要: Within the central neural circuitry for thermoregulation, balance between excitatory and inhibitory inputs to dorsomedial hypothalamus (DMH) determines level of activation brown adipose tissue (BAT) thermogenesis. We employed neuroanatomical in vivo electrophysiological techniques identify a source excitation thermogenesis-promoting neurons DMH that is required cold defense fever. Inhibition median preoptic area (MnPO) blocked BAT thermogenic responses during both PGE2-induced fever exposure. Disinhibition or direct MnPO induced response warm rats. Blockade ionotropic glutamate receptors DMH, brain transection rostral cold-evoked NMDA MnPO-evoked RNAscope technique identified glutamatergic population projects expresses c-Fos following These discoveries relative drive sympathoexcitatory augment our understanding thermoregulatory non-torpid mammals. Our data will contribute development novel therapeutic approaches induce hypothermia treating drug-resistant fever, improving glucose energy homeostasis.