Human cytomegalovirus-IgM seropositivity is not associated with atherogenic alterations of lipid profiles and inflammatory status in ischemic stroke patients: a preliminary study

摘要: Background: Past exposure to human cytomegalovirus has been suggested participate in the pathogenetic events associated with atherosclerotic lesion establishment and progression. However, whether ongoing infection is related plaque instability, subsequent acute cerebral ischemia, relatively unknown. The purpose of this study was evaluate potential relationships between active ischemic stroke, especially regard metabolism inflammation. Methods: Ninety-nine stroke patients, large artery atherosclerosis, were divided into two groups based on presence or absence immunoglobulin M (IgM) (human cytomegalovirus-IgM-positive/human cytomegalovirus-IgM-negative 533:66). Baseline clinical characteristics, inflammatory factors, biochemical assessments compared both groups. Then, all patients cytomegalovirus-IgM-positive quartiles according their high-sensitivity C-reactive protein levels, respectively, risk factors compared. Finally, correlations (high-sensitivity white blood cell count) other atherosclerosis -negative subjects evaluated. Results: An association cytomegalovirus-IgM seropositivity atherogenic modification status not found study. Both age count increased across (P50.001), while low-density lipoprotein cholesterol group (P50.02 0.007, respectively). Multivariate linear regression analysis showed that (P50.002), no factor these subjects. Conclusion: Our provided evidence for direct implication systemic infection, represented by positivity, pathogenesis strokes, particularly those involving instability metabolic disorders.