Vascular inflammation is a missing link for diabetes-enhanced atherosclerotic cardiovascular diseases.

摘要: Diabetes is associated with major life-threatening complications such as a markedly increased risk of cardiovascular disease, even in the presence rigid glycemic control. Indeed, nearly 75% diabetic patients eventually die disease or complications. A striking feature phenotype appearance accelerated atherosclerosis, which resembles atherosclerosis that may be encountered non-diabetic individual, except it more extensive, aggressive, and occurs at an earlier age. Atherosclerosis (or atherosclerotic vascular disease; ASVD), pathological syndrome affecting arterial vessels characterized by narrowing lumen secondary to intravascular buildup fatty material cholesterol, aggregated cellular debris, inflammatory change endothelium. Seemingly distinct, these two well-defined disorders are nevertheless, intimately intricately linked. In fact, pathologies appear linked common signaling pathways shared regulatory systems go awry yet poorly understood manner. recent years, body evidence has been growing suggests inflammation peculiar system, patient. This review aims present empirical underpinning hypothesis vasculature might integrated mechanism connects its attendant