Near infrared laser-controlled drug release of thermoresponsive microgel encapsulated with Fe3O4 nanoparticles

摘要: One major issue in thermosensitive drug delivery systems is the remote, repeatable control of temperature vivo through external stimuli such as light, ultrasound, and magnetic field. In this study, an Fe3O4/p(NIPAM-co-MAA) composite microgel (Nms) was fabricated via copolymerizing NIPAM with MAA water-containing Fe3O4 nanoparticles modified by oleic acid. The photothermal effect thermal-responsibility Nms were investigated adjusting amount reaction, result shows LCST 37.2 °C, which could be elevated to 45.8 °C under laser treatment at 808 nm. release experiment, data show that can released expected rate controlling using nm irradiation vivo. fast final cumulative increased about 25%. Thus, these properties indicate its promising application multi-responsive microgels, especially carriers.