Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

摘要: Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is trophic, paracrine immunomodulatory functions that may have the greatest therapeutic impact vivo. Unlike pharmaceutical treatments deliver a single agent at specific dose, MSCs site regulated secrete bioactive factors signals variable concentrations response local microenvironmental cues. Significant progress has been made understanding biochemical metabolic mechanisms feedback associated with MSC response. The anti-inflammatory capacity of be paramount restoration localized or systemic conditions for normal healing tissue regeneration. Allogeneic treatments, categorized as drug regulatory agencies, widely pursued, new studies demonstrate efficacy autologous therapies, even individuals affected disease state. Safety concerns surrounding allogeneic cell preparations make minimally manipulated therapies an attractive option many regenerative, autoimmune applications.