GFAP and antibodies against NMDA receptor subunit NR2 as biomarkers for acute cerebrovascular diseases
作者： Mureșanu Stanca , D. M. , Mărginean , I. C. , Sorițău
DOI: 10.1111/JCMM.12614
关键词:
摘要: We studied whether the serum levels of glial fibrillary acidic protein (GFAP) and antibodies against N-methyl-d-aspartate receptor subunit NR2 (NR2 RNMDA) can discriminate between intracerebral haemorrhage (ICH) ischaemic stroke (IS) in patients. prospectively recruited patients with suspected (72 confirmed) 52 healthy controls. The type brain lesion (ICH or IS) was established using imaging. GFAP RNMDA were measured blood samples obtained within 12 hrs after onset 24, 48 72 hrs 1 2 weeks later ELISA immunoassay. Improvement diagnostic performance assessed logistic regression models designed to predict diagnosis stroke. peaks early during haemorrhagic lesions (at significantly higher levels), late events, whereas have IS at all time-points. Neither two biomarkers used on its own could sufficiently patients, but when they are combination differentiate stroke, a sensitivity specificity 94% 91%, respectively.
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