Natriuretic hormone--its possible role in fluid and electrolyte disturbances in chronic liver disease.

摘要: Besides intrarenal physical factors and aldosterone, a natriuretic hormone has been postulated to modulate renal tubular sodium resorption in order maintain body fluid homeostasis. To investigate the possible role of activity retention chronic liver disease, effects plasma fraction IV from patients with cirrhosis ascites on transport isolated frog skin excretion rat were compared antinatriferic healthy subjects. While individuals obtained following acute expansion extracellular volume (ECV) significantly inhibited potential difference (PD) by -43·8 ± 5·5% short circuit current (SCC) -41·3 1·7% when applied inner surface, control affected PD -3·8 4·7% -5·2 3·7% SCC -7·3 4·6% -11·7 2·5% respectively. Similar observed fractions IV. In contrast ECV-expanded individuals, which caused marked diuresis natriuresis injected rat, cirrhotic failed affect urinary flow rate, free-water clearance or excretion. The results suggest that at least some may lack an adequate humoral sufficiently promote