Efficacy of Immunotherapy to Ragweed Antigen Tested by Controlled Antigen Exposure

摘要: Background Immunotherapy is a recognized component in the management of allergic rhinitis. Its efficacy has been evaluated number clinical field trials. These methods evaluation are limited by control antigen exposure. Objective A study was designed to evaluate immunotherapy ragweed-induced rhinoconjunctivitis using an environmental exposure unit. Methods Forty-three subjects were grouped into (1) group: ragweed-allergic on maintenance ragweed for at least 2 years (n = 16), (2) positive who had never received and (3) negative ragweed-nonallergic 11). Ragweed specific skin tests IgE levels obtained prior The done room where 2,500 3,000 grains/m 3 maintained over hours. Symptoms recorded every 15 minutes. Results Nasal symptoms group significantly less than after 45 minutes (P .025). Significant differences not observed ocular symptoms. Combined nasal scores 50% 75 .039). Ragweed-specific group. Rhinoconjunctivitis absent throughout. Conclusions Controlled pollen this setting demonstrated that reduced rhinitis but no significant effect This system presents opportunities additional studies respiratory conditions.