Expression of Hepatoma-derived growth factor family members in the adult central nervous system

摘要: Hepatoma-derived growth factor (HDGF) belongs to a polypeptide family containing five additional members called HDGF related proteins 1–4 (HRP-1 -4) and Lens epithelial derived factor. Whereas some such as HRP-2 are expressed in wide range of tissues, the expression others is very restricted. HRP-1 -4 only testis, HRP-3 nervous system. Here we investigated HDGF, central system adult mice on cellular level by immunohistochemistry. In addition performed Western blot analysis various brain regions well neuronal glial cell cultures. was rather evenly throughout all tested with lowest substantia nigra. strongly thalamus, prefrontal parietal cortex, neurohypophysis, cerebellum, bulbus olfactorius, piriform cortex amygdala complex. were found be neurons, astrocytes oligodendrocytes. contrast, strong restricted except for weak oligodendrocytes stem. Although majority neurons positive, like cerebellar granule cells negative. The coexpression glia three many suggests different functions protein that might include proliferation survival. point special function this member cells.