Ecocardiografia de pacientes talassêmicos sem insuficiência cardíaca em tratamento com transfusões sanguíneas e quelação

摘要: BACKGROUND: Patients with thalassemia major present chronic hemolysis and require regular blood transfusions which may cause iron overload cardiomyopathy heart failure. Hemochromatosis is characterized by excessive accumulation in tissues, involvement the main of death patients thalassemia. OBJECTIVE: The aim this study was to evaluate cardiac structure function conventional Doppler echocardiography tissue imaging TM no clinical evidence METHODS: This a prospective observational including 18 (TM) receiving transfusion. To separately anemia transfusion effects, two gender, age, weight, height-matched control groups were included: one healthy individuals (Healthy, n=18) deficient (Anemia, n=18). Statistical analysis performed using ANOVA followed Tukey's test or Kruskal-Wallis's Dunn's test. RESULTS: following echocardiographic variables presented significantly higher values than Anemia Healthy groups: left atrium volume index (Healthy: 16.4±6.08; Anemia: 17.9±7.02; TM: 24.1±8.30 cm3/m2); mitral septal E/Em ratio 6.55±1.60; 6.74±0.74; 8.10±1.31); duration reverse pulmonary vein flow [Healthy: 74.0 (59.0-74.0); 70.5 (67.0-74.0); 111 (87.0-120) ms]. E/A 1.80±0.40; 1.80±0.24; 2.03±0.34). No differences found ventricular structures systolic indexes. CONCLUSION: Conventional allow changes diastolic be identified asymptomatic major.