The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

摘要: Stroke not only causes initial cell death, but also a limited process of repair and recovery. As an overall biological process, stroke has been most often considered from the perspective early phases ischemia, how these inter-relate lead to expansion infarct. However, just as biology later stages becomes better understood, clinical realities indicate that it is now more chronic disease than acute killer. important understand death leads later, recovery so develop integrative view stroke. This progression involves sequential primary secondary injury events, reactive tissue progenitor responses, formation new neuronal circuits. radial: suffers infarct signals, including free radicals inflammatory cytokines, radiate out core trigger regenerative events. Injury processes occur in local site, are triggered connected networks neurons had existed center: damage signals relayed throughout brain network. From relayed, distributed astrocytosis, processes, connections distant areas. In short, emerging data studies development field neural continuum time space progressive events can be 3 Rs biology: radial, regenerative.