Cost-effectiveness of Helicobacter pylori screening followed by eradication treatment for employees in Japan.

摘要: Gastric cancer is the third leading cause of death worldwide. screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based community-based) opportunistic Japan. There were 45 531 gastric deaths 2016, with low detection rates. Helicobacter pylori (H. pylori) followed by eradication treatment recommended high-risk population settings to reduce incidence. The aim this study was evaluate cost-effectiveness H. for a occupational health setting. Decision trees Markov models developed two strategies; antibody test (HPA) no screening. Targeted populations hypothetical cohorts employees aged 20, 30, 40, 50 60 years company payer perspective on lifetime horizon. Per-person costs effectiveness (quality-adjusted life-years) calculated compared. HPA yielded greater benefits at lower cost than One-way probabilistic sensitivity analyses Monte-Carlo simulation showed strong robustness results. prevent Japan, basis cost-effectiveness.