Rho GTPases in transformation and metastasis
作者： Aron B. Jaffe , Alan Hall
DOI: 10.1016/S0065-230X(02)84003-9
关键词:
摘要: During the development and progression of human cancer, cells undergo numerous changes in morphology, proliferation, transcriptional profile. Over past couple decades there have been intense efforts to understand molecular mechanisms involved, members Ras superfamily small GTPases emerged as important players. Mutated versions genes were first identified cancers some 20 years ago, but more recently, Rho branch family has receiving increased attention. In addition experimental evidence implicating GTPase signaling promoting malignant transformation, genetic analysis now revealed a few examples direct alterations encoding regulators GTPases. this review, we discuss transformation metastasis, well progress made toward identifying their biochemical mechanism action.
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