Clinical studies with ACTH and cortisone in renal disease.

摘要: THE DEVASTATING effects of glomerular nephritis and the considerable disability induced by this disease are well known. The fact that has a predilection for children young adults serves as an additional stimulus to search means controlling disease. To date, therapy is limited procedures which ameliorate metabolic abnormalities secondary renal failure or attempts reduce incidence intercurrent infections. dramatic effect pituitary adrenocorticotropic hormone (ACTH) cortisone1exert on course wide variety systemic diseases unknown origin, especially those in antigen-antibody type reaction believed play important etiologic role, stimulated us investigate possible beneficial these hormones patients with nephritis. Furthermore, earlier studies 2 indicating apparent competitive inhibition cortisone excessive sodium retention desoxycorticosterone naturally suggested investigation