Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia
作者： Anja J. Gerrits , Emily A. Leven , Andrew L. Frelinger , Sophie L. Brigstocke , Michelle A. Berny-Lang
DOI: 10.1182/BLOOD-2014-09-602573
关键词:
摘要: Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) patients have microthrombocytopenia, hemorrhage is a major problem. We asked whether eltrombopag, thrombopoietic agent, would increase platelet counts, improve activation, and/or reduce bleeding in WAS/XLT
ashpublications.org
bloodjournal.org
elsevier.com参考文章(49)
Barbara S. Gross, Jonathan I. Wilde, Lynn Quek, Helen Chapel, David L. Nelson, Steve P. Watson, Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI. Blood. ,vol. 94, pp. 4166- 4176 ,(1999) , 10.1182/BLOOD.V94.12.4166
Current protocols in cytometry John Wiley & Sons, Inc.. ,(2001) , 10.1002/0471142956
AS Kestin, CR Valeri, SF Khuri, J Loscalzo, PA Ellis, H MacGregor, V Birjiniuk, H Ouimet, B Pasche, MJ Nelson, The Platelet Function Defect of Cardiopulmonary Bypass. Blood. ,vol. 82, pp. 107- 117 ,(1993) , 10.1182/BLOOD.V82.1.107.BLOODJOURNAL821107
Robert Sokolic, Neal Oden, Fabio Candotti, Assessment of Immature Platelet Fraction in the Diagnosis of Wiskott-Aldrich Syndrome. Frontiers in Pediatrics. ,vol. 3, pp. 49- 49 ,(2015) , 10.3389/FPED.2015.00049
Q Zhu, M Zhang, RM Blaese, JM Derry, A Junker, U Francke, SH Chen, HD Ochs, The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene Blood. ,vol. 86, pp. 3797- 3804 ,(1995) , 10.1182/BLOOD.V86.10.3797.BLOODJOURNAL86103797
B. PSAILA, J. B. BUSSEL, A. L. FRELINGER, B. BABULA, M. D. LINDEN, Y. LI, M. R. BARNARD, C. TATE, E. J. FELDMAN, A. D. MICHELSON, Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia. Journal of Thrombosis and Haemostasis. ,vol. 9, pp. 2302- 2310 ,(2011) , 10.1111/J.1538-7836.2011.04506.X
Lori A. Krueger, Marc R. Barnard, A.L. Frelinger, Mark I. Furman, Alan D. Michelson, Immunophenotypic Analysis of Platelets Current Protocols in Cytometry. ,vol. 19, ,(2002) , 10.1002/0471142956.CY0610S19
John D Grainger, Franco Locatelli, Thirachit Chotsampancharoen, Elena Donyush, Bunchoo Pongtanakul, Patcharee Komvilaisak, Darintr Sosothikul, Guillermo Drelichman, Nongnuch Sirachainan, Susanne Holzhauer, Vladimir Lebedev, Richard Lemons, Dagmar Pospisilova, Ugo Ramenghi, James B Bussel, Kalpana K Bakshi, Malini Iyengar, Geoffrey W Chan, Karen D Chagin, Dickens Theodore, Lisa M Marcello, Christine K Bailey, Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial The Lancet. ,vol. 386, pp. 1649- 1658 ,(2015) , 10.1016/S0140-6736(15)61107-2
Anna Shcherbina, Fred S. Rosen, Eileen Remold-O'Donnell, Pathological events in platelets of Wiskott-Aldrich syndrome patients. British Journal of Haematology. ,vol. 106, pp. 875- 883 ,(1999) , 10.1046/J.1365-2141.1999.01637.X
R. Michael Blaese, Lawrence G. Lum, David G. Tubergen, Laurence Corash, Splenectomy in the Management of the Thrombocytopenia of the Wiskott–Aldrich Syndrome New England Journal of Medicine. ,vol. 302, pp. 892- 896 ,(1980) , 10.1056/NEJM198004173021604